In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and µLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary current sources. We designed and fabricated a current source chip and integrated it into a headstage PCB that weighs 1.37 g. The proposed system provides 10-bit resolution current control for 32 channels, driving µLEDs with up to 4.6 V and sourcing up to 0.9 mA at a refresh rate of 5 kHz per channel. When calibrated against a µLED probe, the system allows linear control of light output power, up to 10 µW per µLED. To demonstrate the capabilities of the system, synthetic sequences of neural spiking activity were produced by driving multiple µLEDs implanted in the hippocampal CA1 area of a freely moving mouse. The high spatial, temporal, and amplitude resolution of the system provides a rich variety of stimulation patterns. Combined with commercially available sampling headstages, the system provides an easy to use back-end, fully utilizing the bi-directional potential of integrated opto-electronic arrays.

中文翻译：

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Outan：一种用于驱动植入自由移动小鼠体内的 µLED 阵列的头戴式系统

在完整的大脑中，可以使用传感电极记录神经活动，并使用光刺激进行操作。带有集成电极和 µLED 的硅探针可以使用单个植入设备检测和控制神经活动。小型自由移动动物录音的小型化解决方案在商业上可用，但刺激是由大的、固定的电流源驱动的。我们设计并制造了一个电流源芯片，并将其集成到一个重 1.37 克的探头 PCB 中。建议的系统为 32 个通道提供 10 位分辨率的电流控制，以高达 4.6 V 的电压驱动 µLED，并以每通道 5 kHz 的刷新率提供高达 0.9 mA 的电流。当针对 µLED 探头进行校准时，该系统允许对光输出功率进行线性控制，每个 µLED 高达 10 µW。为了展示该系统的功能，通过驱动植入自由移动鼠标海马 CA1 区域的多个 µLED 来生成神经尖峰活动的合成序列。该系统的高空间、时间和幅度分辨率提供了丰富多样的刺激模式。结合市售的采样探头，该系统提供了一个易于使用的后端，充分利用了集成光电阵列的双向潜力。