In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and μLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary current sources. We designed and fabricated a current source chip and integrated it into a headstage PCB that weighs 1.37 g. The proposed system provides 10-bit resolution current control for 32 channels, driving μLEDs with up to 4.6 V and sourcing up to 0.9 mA at a refresh rate of 5 kHz per channel. When calibrated against a μLED probe, the system allows linear control of light output power, up to 10 μW per μLED. To demonstrate the capabilities of the system, synthetic sequences of neural spiking activity were produced by driving multiple μLEDs implanted in the hippocampal CA1 area of a freely moving mouse. The high spatial, temporal, and amplitude resolution of the system provides a rich variety of stimulation patterns. Combined with commercially available sampling headstages, the system provides an easy to use back-end, fully utilizing the bi-directional potential of integrated opto-electronic arrays.

中文翻译：

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Outan：一种用于驱动植入自由移动的小鼠中的μLED阵列的头戴式系统。

在完整的大脑中，可以使用感应电极记录神经活动，并使用光刺激进行操纵。带有集成电极和μLED的硅探针可使用单个植入设备检测和控制神经活动。用于小型自由移动动物的记录的微型化解决方案是可商购的，但是刺激是由大型固定电流源驱动的。我们设计并制造了一个电流源芯片，并将其集成到重量为1.37 g的前端PCB中。拟议的系统为32个通道提供10位分辨率的电流控制，以高达4.6V的电压驱动μLED，并以每通道5kHz的刷新率提供高达0.9mA的电流。当根据μLED探头进行校准时，该系统允许线性控制光输出功率，每个μLED高达10μW。为了演示该系统的功能，通过驱动植入自由移动小鼠海马CA1区域的多个μLED，产生了神经突刺活性的合成序列。系统的高空间，时间和振幅分辨率可提供多种刺激模式。结合市售的采样前端，该系统提供了易于使用的后端，充分利用了集成光电阵列的双向电势。