As a frontal node in the primate social brain, the medial prefrontal cortex (MPFC) plays a critical role in coordinating one's own behavior with respect to that of others. Current literature demonstrates that single neurons in the MPFC encode behavior-related variables such as intentions, actions, and rewards, specifically for self and other, and that the MPFC comes into play when reflecting upon oneself and others. The social moderator account of MPFC function can explain maladaptive social cognition in people with autism spectrum disorder, which tips the balance in favor of self-centered perspectives rather than taking into consideration the perspective of others. Several strands of evidence suggest a hypothesis that the MPFC represents different other mental models, depending on the context at hand, to better predict others' emotions and behaviors. This hypothesis also accounts for aberrant MPFC activity in autistic individuals while they are mentalizing others. Expected final online publication date for the Annual Review of Neuroscience, Volume 44 is July 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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内侧前额叶皮层在调节灵长类中自我和他人的神经表征中的作用。

作为灵长类动物社交大脑的额叶节点，内侧前额叶皮层（MPFC）在协调自己的行为与他人的行为方面起着至关重要的作用。当前文献表明，MPFC中的单个神经元编码与行为相关的变量，例如意图，行为和报酬，特别是针对自我和他人，并且MPFC在反思自己和他人时发挥作用。MPFC功能的社会主持人说明可以解释自闭症谱系障碍患者的不良适应性社会认知，这提示了以自我为中心的观点而不是考虑他人观点的平衡。几条证据表明一个假设，即MPFC代表不同的其他心理模型，具体取决于当前的上下文，以便更好地预测其他人的心理模型。情绪和行为。该假设还说明了自闭症患者在思考他人时其MPFC活动异常。《神经科学年度评论》（第44卷）的最终最终在线发布日期为2021年7月。有关修订的估算，请参见http://www.annualreviews.org/page/journal/pubdates。