Feed and drinking water are the most frequently used vehicles for administration of antibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. Therefore, antibiotic formulations should be tested in order to assure their suitability for oral use. In this study, an oral fosfomycin (FOS) formulation was evaluated considering dissolution in water (soft and hard), release kinetics from feed in simulated gastrointestinal fluids and bioavailability after oral administration blended into feed or dissolved in water (soft and hard), to fed and fasted piglets. FOS reached immediate dissolution in soft and hard water. The presence of feed significantly decreased antibiotic dissolution in simulated intestinal medium. Bioavailability was lower when feed was used as a vehicle for FOS administration than when the drug was dissolved in water (soft or hard). The fed or fasted condition of piglets did not affect bioavailability. Probably, FOS interactions with feed components alter its dissolution in the gastrointestinal tract, and only a fraction of the dose would be available for absorption. This information must be considered to support decisions on eligibility of antibiotic pharmaceutical formulations and the vehicle for their administration in order to pursue a responsible use of antibiotics.

中文翻译：

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口服磷霉素制剂与饲料或饮用水之间的潜在相互作用：对仔猪生物利用度的影响。

饲料和饮用水是集约化养猪生产中最常用的抗生素管理工具。药物与饲料和水成分的相互作用可能会影响溶出度和生物利用度。因此，应该对抗生素制剂进行测试，以确保其适合口服使用。在这项研究中，评估了口服磷霉素（FOS）制剂，考虑到其在水中的溶解（软和硬），在模拟胃肠道液中从饲料中释放的动力学以及口服混入饲料或溶于水（软和硬）后的生物利用度，喂食和禁食的仔猪。FOS立即在软水和硬水中溶解。饲料的存在显着降低了抗生素在模拟肠介质中的溶解。当饲料用作FOS给药的载体时，其生物利​​用度要比药物溶于水（软或硬）时的生物利用度低。仔猪的进食或禁食状况不影响生物利用度。FOS与饲料成分的相互作用可能会改变其在胃肠道中的溶解度，只有一小部分剂量可用于吸收。为了追求负责任地使用抗生素，必须考虑这些信息以支持有关抗生素药物制剂及其给药媒介物资格的决定。而只有一小部分剂量可用于吸收。为了追求负责任地使用抗生素，必须考虑这些信息以支持有关抗生素药物制剂及其给药媒介物资格的决定。而只有一小部分剂量可用于吸收。为了追求负责任地使用抗生素，必须考虑这些信息以支持有关抗生素药物制剂及其给药媒介物资格的决定。