Metabolomics is the large-scale study of low-molecular-weight substances in a biological system in a given physiological state at a given time point. Metabolomics can be applied to identify predictors of inter-individual variability in drug response, provide clinicians with data useful for decision-making processes in drug selection, and inform about the pharmacokinetics and pharmacodynamics of a drug. It is, therefore, an exceptional approach for gaining new understanding effects in the field of comparative veterinary pharmacology. However, the incorporation of metabolomics into veterinary pharmacology and toxicology is not yet widespread, and this is probably, at least in part, a result of its highly multidisciplinary nature. This article reviews the potential applications of metabolomics in veterinary pharmacology and therapeutics. It integrates key concepts for designing metabolomics studies and analyzing and interpreting metabolomics data, providing solid foundations for applying metabolomics to the study of drugs in all veterinary species.

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将代谢组学应用于兽医药理学和治疗学

代谢组学是对特定时间点、特定生理状态下生物系统中低分子物质的大规模研究。代谢组学可用于确定药物反应个体间差异的预测因素，为临床医生提供对药物选择决策过程有用的数据，并了解药物的药代动力学和药效学。因此，这是在比较兽医药理学领域获得新的理解效果的一种特殊方法。然而，代谢组学在兽医药理学和毒理学中的应用尚未广泛普及，这可能至少部分是由于其高度多学科性质的结果。本文综述了代谢组学在兽医药理学和治疗学中的潜在应用。