Objectives To compare clinical characteristics and outcomes of infants born to COVID-19 to non COVID-19 mothers at delivery in a community hospital in Queens, New York. Methods Case-control study conducted March 15 to June 15, 2020. Cases were infants born to mothers with laboratory-confirmed COVID-19 infection at delivery. The infant of non COVID-19 mother born before and after each case were selected as controls. Results Of 695 deliveries, 62 (8.9%) infants were born to COVID-19 mothers; 124 controls were selected. Among cases, 18.3% were preterm compared to 8.1% in controls (p=0.04). In preterm cases, birth weight was not significantly different between groups. However, there was a significantly higher proportion of neonatal intensive care unit (NICU) admissions, need for respiratory support, suspected sepsis, hyperbilirubinemia, feeding intolerance and longer length of stay (LOS) in preterm cases. Among term cases, birth weight and adverse outcomes were not significantly different between cases and controls except for more feeding intolerance in cases. All infants born to COVID-19 mothers were COVID-19 negative at 24 and 48 h of life. No infants expired during birth hospitalization. Conclusions Significantly, more infants of COVID-19 mothers were premature compared to controls. Preterm cases were more likely to have adverse outcomes despite having similar birth weight and gestational age. These differences were not seen among full term infants. Health care providers should anticipate the need for NICU care when a COVID-19 mother presents in labor.

中文翻译：

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婴儿结局和母亲分娩时的 COVID-19 状况


目的 比较纽约州皇后区社区医院分娩时感染 COVID-19 的婴儿与非 COVID-19 母亲所生婴儿的临床特征和结局。方法 病例对照研究于2020年3月15日至6月15日进行。病例是分娩时实验室确诊感染COVID-19的母亲所生的婴儿。选择每个病例前后出生的非COVID-19母亲的婴儿作为对照。结果 在 695 次分娩中，有 62 名 (8.9%) 婴儿是由 COVID-19 母亲所生；选择了 124 个对照。在病例中，18.3% 为早产，而对照组为 8.1%（p=0.04）。在早产病例中，各组之间的出生体重没有显着差异。然而，早产病例中新生儿重症监护病房 (NICU) 入院、需要呼吸支持、疑似败血症、高胆红素血症、喂养不耐受和住院时间 (LOS) 延长的比例明显较高。在足月病例中，病例和对照之间的出生体重和不良结局没有显着差异，只是病例中喂养不耐受程度更高。 COVID-19 母亲所生的所有婴儿在出生后 24 小时和 48 小时时均为 COVID-19 阴性。没有婴儿在分娩住院期间过期。结论 值得注意的是，与对照组相比，COVID-19 母亲所生的早产婴儿更多。尽管出生体重和胎龄相似，早产病例更有可能出现不良后果。这些差异在足月婴儿中并未观察到。当 COVID-19 母亲临产时，医疗保健提供者应预见到 NICU 护理的需要。