Dynamic RNA modifications have been a burgeoning area in the last decade since the concept of 'RNA epigenetics' was proposed [1]. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotic cells. It can be installed by 'writers', removed by 'erasers,' recognized by 'readers,' and dynamically regulate the fate of methylated RNA. Until recently, the roles of reversible RNA methylation in chromatin and transcriptional regulation were not adequately studied. We discuss the new discoveries and insights into the chromatin and transcriptional regulation by m6A through two pathways: 1) effects of m6A on mRNAs encoding histone modifiers and transcriptional factors; 2) m6A regulation of chromatin-associated regulatory RNAs. Additionally, we provide an outlook on how the transcriptional regulation by RNA m6A could add an additional critical layer to transcriptional regulation.

中文翻译：

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通过可逆 RNA 甲基化进行染色质和转录调控。


自“RNA表观遗传学”概念提出以来，动态RNA修饰在过去十年中一直是一个新兴领域[1]。 N6-甲基腺苷 (m6A) 是真核细胞中最丰富的 mRNA 修饰。它可以被“写入者”安装，被“擦除器”删除，被“读者”识别，并动态调节甲基化RNA的命运。直到最近，可逆 RNA 甲基化在染色质和转录调控中的作用尚未得到充分研究。我们通过两条途径讨论 m6A 对染色质和转录调控的新发现和见解：1）m6A 对编码组蛋白修饰剂和转录因子的 mRNA 的影响； 2) 染色质相关调节RNA的m6A调节。此外，我们还展望了 RNA m6A 的转录调控如何为转录调控添加额外的关键层。