Dynamic RNA modifications have been a burgeoning area in the last decade since the concept of 'RNA epigenetics' was proposed [1]. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotic cells. It can be installed by 'writers', removed by 'erasers,' recognized by 'readers,' and dynamically regulate the fate of methylated RNA. Until recently, the roles of reversible RNA methylation in chromatin and transcriptional regulation were not adequately studied. We discuss the new discoveries and insights into the chromatin and transcriptional regulation by m6A through two pathways: 1) effects of m6A on mRNAs encoding histone modifiers and transcriptional factors; 2) m6A regulation of chromatin-associated regulatory RNAs. Additionally, we provide an outlook on how the transcriptional regulation by RNA m6A could add an additional critical layer to transcriptional regulation.

中文翻译：

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染色质和转录调控通过可逆的RNA甲基化。

自从提出“ RNA表观遗传学”的概念以来，动态RNA修饰一直是最近十年的新兴领域[1]。N6-甲基腺苷（m6A）是真核细胞中最丰富的mRNA修饰。它可以由“作家”安装，由“橡皮擦”删除，由“读者”识别，并动态调节甲基化RNA的命运。直到最近，还没有充分研究可逆RNA甲基化在染色质和转录调控中的作用。我们通过两个途径讨论了m6A对染色质和转录调控的新发现和见解：1）m6A对编码组蛋白修饰子和转录因子的mRNA的影响；2）染色质相关调控RNA的m6A调控。此外，