In recent years, remarkable progress has been made toward understanding the three-dimensional (3D) organisation of genomes and the influence of genome organisation on gene regulation. Although 3D genome organisation probably plays a crucial role in embryo development, animal studies addressing the developmental roles of chromosome topology are only just starting to emerge. Zebrafish, an important model system for early development, have already contributed important advances in understanding the developmental consequences of perturbation in 3D genome organisation. Zebrafish have been used to determine the effects of mutations in proteins responsible for 3D genome organisation: cohesin and CTCF. In this review, we highlight research to date from zebrafish that has provided insight into how 3D genome organisation contributes to tissue-specific gene regulation and embryo development.

中文翻译：

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斑马鱼发育中的三维基因组


近年来，在理解基因组的三维（3D）组织以及基因组组织对基因调控的影响方面取得了显着进展。尽管 3D 基因组组织可能在胚胎发育中发挥着至关重要的作用，但解决染色体拓扑发育作用的动物研究才刚刚开始出现。斑马鱼是早期发育的重要模型系统，在理解 3D 基因组组织扰动的发育后果方面已经做出了重要进展。斑马鱼已被用来确定负责 3D 基因组组织的蛋白质突变的影响：粘连蛋白和 CTCF。在这篇综述中，我们重点介绍了斑马鱼迄今为止的研究，这些研究深入了解了 3D 基因组组织如何促进组织特异性基因调控和胚胎发育。