In recent years, remarkable progress has been made toward understanding the three-dimensional (3D) organisation of genomes and the influence of genome organisation on gene regulation. Although 3D genome organisation probably plays a crucial role in embryo development, animal studies addressing the developmental roles of chromosome topology are only just starting to emerge. Zebrafish, an important model system for early development, have already contributed important advances in understanding the developmental consequences of perturbation in 3D genome organisation. Zebrafish have been used to determine the effects of mutations in proteins responsible for 3D genome organisation: cohesin and CTCF. In this review, we highlight research to date from zebrafish that has provided insight into how 3D genome organisation contributes to tissue-specific gene regulation and embryo development.

中文翻译：

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斑马鱼发育中的三维基因组。

近年来，在了解基因组的三维（3D）组织以及基因组组织对基因调控的影响方面取得了显着进展。尽管3D基因组的组织可能在胚胎发育中起着至关重要的作用，但有关染色体拓扑发展作用的动物研究才刚刚开始。斑马鱼是早期开发的重要模型系统，已经在理解3D基因组组织扰动的发展后果方面做出了重要的进展。斑马鱼已被用于确定负责3D基因组组织的蛋白质（粘着蛋白和CTCF）中突变的影响。在这篇评论中，