Individuals with a comorbid diagnosis of Down syndrome (DS) and autism spectrum disorder (ASD) have been found to exhibit greater deficits in expressive communication than individuals with DS only. We hypothesized that individuals with a comorbid diagnosis (n = 430) would have significantly lower Communication Matrix scores and specifically social communication scores than individuals with DS alone (n = 4,352). In a sample of 4,782 individuals with DS, scores for individuals with a comorbid diagnosis were on average 18.01 points and 7.26 points lower for total score and social score respectively as compared to individuals with DS. Comorbid diagnosis accounted for 10.5% of the variance in communication scores. Between-group differences in referential gestures and symbolic communication behaviors were also observed.

中文翻译：

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在具有自闭症谱系障碍和唐氏综合症双重诊断的个体的横截面样本中探索表达沟通技巧。

已发现患有唐氏综合症 (DS) 和自闭症谱系障碍 (ASD) 的个体在表达交流方面表现出比仅患有 DS 的个体更大的缺陷。我们假设有共病诊断的个体 (n = 430) 的沟通矩阵得分和特别是社会沟通得分明显低于单独患有 DS 的个体 (n = 4,352)。在 4,782 名 DS 患者的样本中，与 DS 患者相比，共病诊断患者的总分和社会得分平均分别低 18.01 分和 7.26 分。共病诊断占沟通评分差异的 10.5%。还观察到参考手势和象征性交流行为的组间差异。