The subclass of compounds that have the nucleus 1, 4-naphthoquinone is the most diverse class of quinones, which have a large number of substances and have useful applications ranging from medicinal chemistry to application in materials with special properties. The introduction of one or two substituents with the sulfur heteroatom in the naphthoquinone nucleus generates products containing alkyl and aryl groups that amplify certain biological properties against bacteria, viruses, and fungi. There are several methods of preparing these compounds, mainly from low molecular weight naphthoquinones with two electrophilic sites capable of reacting with sulfides generating diversity and new classes of compounds, including new sulfur heterocycles and sulfur heterocycles fused with naphthoquinones. These compounds have been shown to be bioactive against several biological targets. This review will describe the methods of their synthesis and, when applicable, their biological activities.

中文翻译：

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Mono-和Bis-Thionaphthoquinones 的合成策略。

具有核1, 4-萘醌的化合物的亚类是最多样化的醌类，其具有大量的物质并且具有从药物化学到具有特殊性质的材料的应用的有用应用。在萘醌核中引入一个或两个带有硫杂原子的取代基会产生含有烷基和芳基的产物，这些产物增强了对细菌、病毒和真菌的某些生物学特性。有几种制备这些化合物的方法，主要是从具有两个亲电子位点的低分子量萘醌类化合物中，这些亲电子位点能够与硫化物反应产生多样性和新的化合物类别，包括新的硫杂环和与萘醌稠合的硫杂环。这些化合物已被证明对几种生物靶标具有生物活性。这篇综述将描述它们的合成方法，并在适用时描述它们的生物活性。