A vast share of the population-attributable risk for autism relates to inherited polygenic risk. A growing number of studies in the past five years have indicated that inherited susceptibility may operate through a finite number of early developmental liabilities that, in various permutations and combinations, jointly predict familial recurrence of the convergent syndrome of social communication disability that defines the condition. Here, we synthesize this body of research to derive evidence for a novel developmental substructure for autism, which has profound implications for ongoing discovery efforts to elucidate its neurobiological causes, and to inform future clinical and biomarker studies, early interventions, and personalized approaches to therapy. Expected final online publication date for the Annual Review of Clinical Psychology, Volume 17 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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孤独症新兴发育子结构的临床和翻译意义。

自闭症的人群归因风险中有很大一部分与遗传的多基因风险有关。在过去五年中，越来越多的研究表明，遗传易感性可能通过有限数量的早期发育责任来起作用，这些责任在各种排列和组合下共同预测了定义该状况的社交交往残疾趋同综合症的家族性复发。在这里，我们综合了这一研究机构，为自闭症的新型发育亚结构提供了证据，这对正在进行的发现努力阐明其神经生物学原因，并为将来的临床和生物标志物研究，早期干预以及个性化治疗方法提供了深刻的启示。 。预计《临床心理学年度评论》的最终在线发布日期，