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Intergenerational transmission of depression risk: Mothers' neural response to reward and history of depression are associated with daughters' neural response to reward across adolescence.
Journal of Psychopathology and Clinical Science ( IF 3.1 ) Pub Date : 2021-02-04 , DOI: 10.1037/abn0000662
Paige Ethridge 1 , Clara Freeman 1 , Aislinn Sandre 1 , Iulia Banica 1 , Melanie A Dirks 1 , Anna Weinberg 1
Affiliation  

Impaired reward responsiveness, a construct of the RDoC positive valence systems (PVS), prospectively predicts depression onset and may therefore represent an important marker of risk. Neural structures implicated in reward processing undergo substantial change during adolescence, a period of heightened risk for depression, particularly for those with a family history of the disorder. However, it is not clear whether familial transmission of PVS functioning also changes across adolescence, nor whether a family history of depression influences normative development of the PVS. To address these questions, mothers and their adolescent daughters each completed a monetary reward guessing task while an electroencephalogram was recorded (N = 109 dyads). Daughters' pubertal status significantly moderated the association between mothers' and daughters' reward processing in the delta frequency, such that there was a negative association for daughters in early puberty that shifted toward a positive association in later puberty. Furthermore, for never-depressed daughters without a maternal history of depression, more advanced pubertal development was associated with increased reward-related power in the delta frequency, whereas, for daughters with a maternal history of depression, more advanced pubertal development was associated with reduced power in the delta frequency. These data indicate that biomarkers of risk for psychopathology may differ as a function of both familial risk and developmental status. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译:

抑郁风险的代际传递:母亲对奖赏的神经反应和抑郁病史与女儿对青春期奖赏的神经反应有关。

奖励反应受损是 RDoC 正价系统 (PVS) 的一种构造,可前瞻性地预测抑郁症的发作,因此可能代表一个重要的风险标志。与奖励处理有关的神经结构在青春期会发生重大变化,这是抑郁症风险增加的时期,特别是对于那些有抑郁症家族史的人。然而,尚不清楚 PVS 功能的家族传播是否也会在整个青春期发生变化,也不清楚抑郁症家族史是否会影响 PVS 的规范发展。为了解决这些问题,母亲和她们青春期的女儿各自完成了一项金钱奖励猜测任务,同时记录了脑电图(N = 109 dyads)。女儿的青春期状况显着调节了母亲之间的关联 和女儿在 delta 频率中的奖励处理,因此在青春期早期对女儿有负相关,在青春期后期转向正相关。此外,对于没有母亲抑郁病史的从未抑郁的女儿,更先进的青春期发育与增量频率中奖赏相关能力的增加有关,而对于有母亲抑郁病史的女儿,更先进的青春期发育与降低有关三角洲频率的功率。这些数据表明,精神病理学风险的生物标志物可能因家族风险和发育状况而异。(PsycInfo 数据库记录 (c) 2022 APA,保留所有权利)。因此,青春期早期对女儿的负面关联在青春期后期转变为正面关联。此外,对于没有母亲抑郁病史的从未抑郁的女儿,更先进的青春期发育与增量频率中奖赏相关能力的增加有关,而对于有母亲抑郁病史的女儿,更先进的青春期发育与降低有关三角洲频率的功率。这些数据表明,精神病理学风险的生物标志物可能因家族风险和发育状况而异。(PsycInfo 数据库记录 (c) 2022 APA,保留所有权利)。因此,青春期早期对女儿的负面关联在青春期后期转变为正面关联。此外,对于没有母亲抑郁病史的从未抑郁的女儿,更先进的青春期发育与增量频率中奖赏相关能力的增加有关,而对于有母亲抑郁病史的女儿,更先进的青春期发育与降低有关三角洲频率的功率。这些数据表明,精神病理学风险的生物标志物可能因家族风险和发育状况而异。(PsycInfo 数据库记录 (c) 2022 APA,保留所有权利)。更高级的青春期发育与 delta 频率的奖励相关功率增加有关,而对于有母亲抑郁史的女儿,更高级的青春期发育与 delta 频率的功率降低有关。这些数据表明,精神病理学风险的生物标志物可能因家族风险和发育状况而异。(PsycInfo 数据库记录 (c) 2022 APA,保留所有权利)。更高级的青春期发育与 delta 频率的奖励相关功率增加有关,而对于有母亲抑郁史的女儿,更高级的青春期发育与 delta 频率的功率降低有关。这些数据表明,精神病理学风险的生物标志物可能因家族风险和发育状况而异。(PsycInfo 数据库记录 (c) 2022 APA,保留所有权利)。
更新日期:2021-02-04
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