Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2021-06-21 , DOI: 10.1146/annurev-biochem-071520-112507 Benjamin C McIlwain 1 , Michal T Ruprecht 1 , Randy B Stockbridge 1, 2
Microorganisms contend with numerous and unusual chemical threats and have evolved a catalog of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F−), a common xenobiotic in natural environments that causes broad-spectrum harm to metabolic pathways. This review focuses on advances in the last ten years toward understanding the microbial response to cytoplasmic accumulation of F−, with a special emphasis on the structure and mechanisms of the proteins that microbes use to export fluoride: the CLCF family of F−/H+ antiporters and the Fluc/FEX family of F− channels.
中文翻译:
氟离子膜出口商
微生物应对众多不寻常的化学威胁,并进化出一系列抗性机制作为回应。一种特别古老的有害威胁是由氟离子 (F - ) 构成的,它是自然环境中一种常见的异生物质,会对代谢途径造成广谱危害。这篇综述着重于过去十年在了解微生物对 F -细胞质积累的反应方面取得的进展,特别强调了微生物用来输出氟化物的蛋白质的结构和机制: F - /H的 CLC F家族+反转运蛋白和 F -通道的 Fluc/FEX 家族。