In this paper, we present a comprehensive assessment of dielectric modulated accumulation mode field-effect transistor (AMFET) architecture for label-free biosensing in comparison with inversion mode field-effect transistor (IMFET) architecture. The underlying physics of the AMFET and IMFET biosensors was explored by investigating variation in the conduction band and the electron concentration profile (e⁻CP) under both ON-state and OFF-state due to charged and neutral bio molecule immobilisation. Subsequently, essential sensitivity parameters are estimated for biosensing. It is observed that the variation in electron concentration profile has a huge impact on the drain current and threshold voltage. Sensitivity evaluation predicts AMFET to have improved $I_{\mathit{ON}}$/$I_{\mathit{OFF}}$, OFF-current and threshold (${\text{V}}_{\mathit{TH}}$) shift. AMFET shows enhanced sensitivity to charged biomolecules over neutral bio molecules. From the investigations done, the AMFET has outperformed at lower bias and fails to predict optimum results at higher bias compared to IMFET. This leaves a choice to use the desired device as per the biasing availability for label-free detection of the biomolecules.

在本文中，我们将对介电调制累积模式场效应晶体管（AMFET）体系结构进行无标签生物传感的全面评估，与反向模式场效应晶体管（IMFET）体系结构进行比较。通过研究由于带电和中性生物分子固定而导致的导通带和电子浓度分布（e ^- CP）在导通状态和截止状态下的变化，探索了AMFET和IMFET生物传感器的基本物理原理。随后，估计用于生物传感的基本灵敏度参数。可以看出，电子浓度分布的变化对漏极电流和阈值电压有很大的影响。灵敏度评估预测AMFET将有所改善${\mathrm{一世}}_{\mathit{上}}$/${\mathrm{一世}}_{\mathit{离开}}$，OFF电流和阈值（${\text{伏特}}_{\mathit{TH}}$） 转移。与中性生物分子相比，AMFET对带电生物分子显示出更高的敏感性。从所做的研究来看，与IMFET相比，AMFET在较低的偏置下表现出色，并且无法预测在较高的偏置下的最佳结果。根据生物的无标记检测的偏倚可用性，这留下了使用所需设备的选择。