IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature,Brain Pathology

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IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
Brain Pathology ( IF 5.8 ) Pub Date : 2021-05-07 , DOI: 10.1111/bpa.12959
Ellen K Chang ₁ , Matthew A Smith-Cohn _{2,

3} , Benita Tamrazi ₄ , Jianling Ji ₅ , Mark Krieger ₆ , Matthias Holdhoff ₇ , Charles G Eberhart ₈ , Ashley S Margol ₁ , Jennifer A Cotter ₅

Affiliation

Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH-mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature.

中文翻译：

青少年和青壮年IDH突变脑干胶质瘤三例报告并文献复习

异柠檬酸脱氢酶 (IDH) 突变在儿科和青少年神经胶质瘤中很少见。我们最近确定了三名患有 IDH 突变低级别脑干神经胶质瘤的青少年/年轻成人 (AYA) 患者，这些患者具有几个共同的关键临床病理学和分子特征。我们讨论这三个案例并回顾当前的文献。

更新日期：2021-07-01

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