Dampened behavioral inhibition and overactive behavioral approach motivation systems (i.e. BIS/BAS) are associated with cannabis use disorder (CUD), although the underlying neural mechanisms of these alterations have not yet been examined. The brain’s executive control network (ECN) plays a role in decision-making and is associated with BIS/BAS. In this study, we tested the hypothesis that altered ECN resting-state functional connectivity (rsFC) underlies dysfunctional behavioral inhibition and approach motivation in cannabis users. To that end, we collected resting-state functional magnetic resonance imaging scans in 86 cannabis using adults and 59 non-using adults to examine group differences in the relationship between ECN rsFC and BIS/BAS. Our results showed that BIS was positively correlated with left ECN rsFC in cannabis users, while it was positively correlated with right ECN rsFC in non-users. There was a trend-level moderation effect of group on the association between BIS/BAS and ECN rsFC, showing a weaker association in BIS/BAS and ECN rsFC in cannabis users compared to non-users. An exploratory mediation analysis found that the severity of CUD mediated the relationship between users’ BIS scores and left ECN rsFC. These findings suggest that cannabis use may lead to dysregulation in typical ECN functional organization related to BIS/BAS.

中文翻译：

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成年大麻使用者的行为抑制和接近动机系统 (BIS/BAS) 与内在大脑网络连通性之间的关系

受抑制的行为抑制和过度活跃的行为方法动机系统（即 BIS/BAS）与大麻使用障碍 (CUD) 相关，尽管尚未研究这些改变的潜在神经机制。大脑的执行控制网络（ECN）在决策中发挥作用，并与 BIS/BAS 相关联。在这项研究中，我们测试了改变 ECN 静息状态功能连接 (rsFC) 的假设是大麻使用者功能失调的行为抑制和接近动机的基础。为此，我们收集了 86 名使用大麻的成年人和 59 名未使用大麻的成年人的静息态功能磁共振成像扫描，以检查 ECN rsFC 和 BIS/BAS 之间关系的群体差异。我们的结果表明，BIS 与大麻使用者的左 ECN rsFC 呈正相关，而在非用户中它与正确的 ECN rsFC 呈正相关。群体对 BIS/BAS 和 ECN rsFC 之间的关联有趋势级调节作用，表明与非用户相比，大麻用户在 BIS/BAS 和 ECN rsFC 之间的关联较弱。一项探索性中介分析发现，CUD 的严重程度中介了用户的 BIS 分数与左 ECN rsFC 之间的关系。这些发现表明，使用大麻可能导致与 BIS/BAS 相关的典型 ECN 功能组织失调。一项探索性中介分析发现，CUD 的严重程度中介了用户的 BIS 分数与左 ECN rsFC 之间的关系。这些发现表明，使用大麻可能导致与 BIS/BAS 相关的典型 ECN 功能组织失调。一项探索性中介分析发现，CUD 的严重程度中介了用户的 BIS 分数与左 ECN rsFC 之间的关系。这些发现表明，使用大麻可能导致与 BIS/BAS 相关的典型 ECN 功能组织失调。