Transcriptional profiling of Microtus fortis responses to S. japonicum: New sight into Mf-Hsp90α resistance mechanism,Parasite Immunology

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Transcriptional profiling of Microtus fortis responses to S. japonicum: New sight into Mf-Hsp90α resistance mechanism
Parasite Immunology ( IF 1.4 ) Pub Date : 2021-05-07 , DOI: 10.1111/pim.12842
Dehui Xiong ₁ , Saiqun Luo ₁ , Kunlu Wu ₁ , Yuanjing Yu ₂ , Jiameng Sun ₁ , Yanpeng Wang ₁ , Jingping Hu ₁ , Weixin Hu ₁

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Schistosomiasis is a parasitic disease with a chronic debilitating character caused by parasitic flatworms of the genus Schistosoma. The main disease-causing species of Schistosoma in China is S. japonicum. M fortis has been proved to be a nonpermissive host of S. japonicum. Mf-HSP90α (Microtus fortis heat shock protein 90alpha), the homologue of HSP90α, display anti-schistosome effect in vitro and in vivo. In the current study, in order to investigate the mechanism of anti-schistosome effect of Mf-HSP90α, we conducted RNA-Seq to obtain the transcriptome profile of M. fortis liver infected with S. japonicum at different time points.

更新日期：2021-07-16

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