Amino acid sequence identification of goji berry cyclic peptides and anticervical carcinoma activity detection,Journal of Peptide Science

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Amino acid sequence identification of goji berry cyclic peptides and anticervical carcinoma activity detection
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2021-05-06 , DOI: 10.1002/psc.3326
Hongxia Ji ₁ , Junxia Ma ₁ , Lianjun Guo ₁ , Yongmei Huang ₁ , Weihong Wang ₁ , Xiuyan Sun ₁ , Rongchun Sun ₁

Affiliation

The goji berry is widely used as tonics; however, the antihuman cervical carcinoma effect and underlying mechanism of goji berry peptide remain to be elucidated. The cyclic peptides are appealing targets in antitumor agent development, and in current study, three novel goji berry cyclic peptides (GCPs) were isolated and amino acid sequence identified. Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa cells in G0/G1 phase significantly. Furthermore, the GCP-1 also inhibited the cervical carcinoma growth in vivo. Moreover, GCP-1 suppressed the cyclin expression and activated the caspase cascade and poly(ADP-ribose) polymerase. Of note, GCP-1 may be a promising novel inhibitor of human cervical cancer.

中文翻译：

枸杞环肽氨基酸序列鉴定及抗宫颈癌活性检测

枸杞被广泛用作滋补品；然而，枸杞肽的抗人宫颈癌作用和潜在机制仍有待阐明。环肽是抗肿瘤药物开发中有吸引力的靶点，在目前的研究中，分离出三种新型枸杞环肽 (GCP) 并确定了氨基酸序列。其中，GCP-1(Cycle-(Trp-Glu-His-Thr))抑制增殖并诱导人宫颈癌(HeLa)细胞凋亡，显着阻断G0/G1期HeLa细胞。此外，GCP-1 还抑制了体内宫颈癌的生长。此外，GCP-1 抑制细胞周期蛋白表达并激活半胱天冬酶级联反应和聚（ADP-核糖）聚合酶。值得注意的是，GCP-1 可能是一种很有前景的新型人类宫颈癌抑制剂。

更新日期：2021-07-06

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