Impact of beta-2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment,CNS Neuroscience & Therapeutics

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Impact of beta-2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-05-07 , DOI: 10.1111/cns.13649
Feng Tang ₁ , Yu-Hang Zhao ₁ , Qing Zhang ₁ , Wei Wei ₁ , Su-Fang Tian ₂ , Chen Li ₁ , Jie Yao ₃ , Ze-Fen Wang ₄ , Zhi-Qiang Li ₁

Affiliation

High immune cell infiltration in gliomas establishes an immunosuppressive tumor microenvironment, which in turn promotes resistance to immunotherapy. Hence, it is important to identify novel targets associated with high immune cell infiltration in gliomas. Our previous study showed that serum levels of beta-2 microglobulin (B2M) in lower-grade glioma patients were lower than those in glioblastoma patients. In the present study, we focused on exploring the roles of B2M in glioma immune infiltration.

中文翻译：

β2微球蛋白表达通过调节肿瘤免疫微环境对胶质瘤患者生存的影响

胶质瘤中的高免疫细胞浸润建立了免疫抑制性肿瘤微环境，进而促进了对免疫治疗的抵抗。因此，重要的是确定与胶质瘤中高免疫细胞浸润相关的新靶点。我们之前的研究表明，低级别胶质瘤患者的血清 β-2 微球蛋白 (B2M) 水平低于胶质母细胞瘤患者。在本研究中，我们专注于探索 B2M 在胶质瘤免疫浸润中的作用。

更新日期：2021-07-09

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