Purpose of Review

Chronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain.

Recent Findings

Flavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6.

Summary

Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.

中文翻译：

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黄酮类化合物治疗神经性疼痛

审查目的

慢性疼痛继续给美国医疗保健系统带来巨大负担。尽管进行了广泛的研究，神经病理性疼痛是一种常见的慢性疼痛，仍然特别难以治疗。当前的药理学方案发挥有限的功效和广泛的、潜在危险的副作用。本综述对有关黄酮类化合物在治疗神经性疼痛中的作用的文献进行了全面的临床前评估。

最近的发现

类黄酮是天然存在的化合物，存在于植物和各种膳食来源中，可能对神经性疼痛具有潜在益处。许多动物模型研究已经证明了这种益处，包括逆转痛觉过敏和异常性疼痛。黄酮类化合物还表现出与神经性疼痛相关的抗炎作用，这可以通过多种促炎介质的减少来证明，例如 TNF-α、NF-κB、IL-1β 和 IL-6。

概括

在临床前模型中，类黄酮代表了一种潜在的神经病理性疼痛的新治疗方式，尽管目前尚未探索人类临床证据。