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An autopsy case of sodium nitrite-induced methemoglobinemia with various post-mortem analyses
Forensic Science, Medicine and Pathology ( IF 1.8 ) Pub Date : 2021-05-07 , DOI: 10.1007/s12024-021-00378-w
Chungsu Hwang 1 , Seong-Hoon Yeon 2 , Jinmi Jung 3 , Joo-Young Na 1
Affiliation  

The use of sodium nitrite in suicide has become more common among young adults in the Republic of Korea. This report details the case of a 28-year-old man; the man had posted on a social network service detailing his attempt at suicide at 13:45. In the posted article, he stated that he had ingested 84 g of sodium nitrite. A post-mortem (PM) inspection was performed at 21:00, and peripheral blood (PB) was collected. An autopsy was performed approximately 44 h after death. The victim’s face was dark brown in color, but the color of his oral mucosa was bright red. Toxicological analyses revealed 33% and 26% methemoglobinemia in the PB collected during PM inspection and autopsy, respectively. The concentration of nitrate in the PB collected during PM inspection, and PB and cardiac blood collected during the autopsy were 220.6 mg/L, 220.0 mg/L, and 218.5 mg/L, respectively. Nitrate was also detected in the pericardial fluid and cerebrospinal fluid at levels of 91.7 mg/L and 50.5 mg/L, respectively. The cause of death was determined to be methemoglobinemia-induced hypoxia due to sodium nitrite ingestion. This intoxication case informs some novel points about nitrite intoxication; the concentration of methemoglobin decreased during the PM period, while the concentration of nitrate was stable. There was no difference in the concentration of nitrate between cardiac and peripheral blood. Nitrate could be detected in the pericardial fluid and cerebrospinal fluid. This new information is helpful for better identifying future cases of nitrite intoxication.



中文翻译:

一例亚硝酸钠引起的高铁血红蛋白血症的尸检案例及各种尸检分析

在大韩民国的年轻人中,亚硝酸钠用于自杀的情况越来越普遍。这份报告详细介绍了一名 28 岁男子的案例;该男子在社交网络服务上发布了他在 13 点 45 分企图自杀的详细信息。在张贴的文章中,他说他摄入了 84 克亚硝酸钠。21:00进行尸检(PM),采集外周血(PB)。尸体解剖在死后大约 44 小时进行。受害人面部呈深褐色,但口腔黏膜呈鲜红色。毒理学分析显示在 PM 检查和尸检期间收集的 PB 中分别有 33% 和 26% 的高铁血红蛋白血症。PM检查采集的PB和尸检采集的PB和心脏血中硝酸盐浓度分别为220.6 mg/L、220.0 mg/L和218。分别为 5 毫克/升。在心包液和脑脊液中也检测到硝酸盐,浓度分别为 91.7 mg/L 和 50.5 mg/L。死因被确定为由于摄入亚硝酸钠引起的高铁血红蛋白血症引起的缺氧。这个中毒案例告诉了一些关于亚硝酸盐中毒的新观点;PM期间高铁血红蛋白浓度下降,而硝酸盐浓度稳定。心脏和外周血之间的硝酸盐浓度没有差异。心包液和脑脊液中可检出硝酸盐。这一新信息有助于更好地识别未来的亚硝酸盐中毒病例。死因被确定为由于摄入亚硝酸钠引起的高铁血红蛋白血症引起的缺氧。这个中毒案例告诉了一些关于亚硝酸盐中毒的新观点;PM期间高铁血红蛋白浓度下降,而硝酸盐浓度稳定。心脏和外周血之间的硝酸盐浓度没有差异。心包液和脑脊液中可检出硝酸盐。这一新信息有助于更好地识别未来的亚硝酸盐中毒病例。死因被确定为由于摄入亚硝酸钠引起的高铁血红蛋白血症引起的缺氧。这个中毒案例告诉了一些关于亚硝酸盐中毒的新观点;PM期间高铁血红蛋白浓度下降,而硝酸盐浓度稳定。心脏和外周血之间的硝酸盐浓度没有差异。心包液和脑脊液中可检出硝酸盐。这一新信息有助于更好地识别未来的亚硝酸盐中毒病例。心脏和外周血之间的硝酸盐浓度没有差异。心包液和脑脊液中可检出硝酸盐。这一新信息有助于更好地识别未来的亚硝酸盐中毒病例。心脏和外周血之间的硝酸盐浓度没有差异。心包液和脑脊液中可检出硝酸盐。这一新信息有助于更好地识别未来的亚硝酸盐中毒病例。

更新日期:2021-05-07
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