Most currently recommended therapies for metabolic dysfunction-associated fatty liver disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and compiled the most recent research into possible forms of programmed cell death in MAFLD, including apoptosis, necroptosis, autophagy, pyroptosis and ferroptosis. Here, we summarize the state of knowledge on the signaling mechanisms for each type and, based on their characteristics, discuss how they might be relevant in MAFLD-related pathological mechanisms. Although significant challenges exist in the translation of fundamental science into clinical therapy, this review should provide a theoretical basis for innovative MAFLD clinical treatment plans that target programmed cell death.

中文翻译：

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针对代谢功能障碍相关脂肪肝疾病 (MAFLD) 中的程序性细胞死亡：一种有前途的新疗法

目前大多数推荐的代谢功能障碍相关脂肪肝疾病 (MAFLD) 的治疗方法包括饮食控制和运动疗法。我们搜索了 PubMed，并汇编了关于 MAFLD 中程序性细胞死亡可能形式的最新研究，包括细胞凋亡、坏死性凋亡、自噬、细胞焦亡和铁死亡。在这里，我们总结了每种类型的信号机制的知识状态，并根据它们的特征，讨论它们如何与 MAFLD 相关的病理机制相关。尽管将基础科学转化为临床治疗存在重大挑战，但这篇综述应该为针对程序性细胞死亡的创新 MAFLD 临床治疗计划提供理论基础。