Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions and scored 30,000 functionally representative yeast gene pairs for dynamic, differential interactions. Different conditions revealed novel differential interactions, which often uncovered functional connections between distantly related gene pairs. However, the majority of observed genetic interactions remained unchanged in different conditions, suggesting that the global yeast genetic interaction network is robust to environmental perturbation and captures the fundamental functional architecture of a eukaryotic cell.

与遗传变异相关的表型可以通过与其他遗传变异（GxG）、与环境（GxE）或两者（GxGxE）的相互作用而改变。酵母遗传相互作用已在全球范围内绘制，但尚未系统地研究环境对遗传网络可塑性的影响。为了评估遗传网络的环境重新布线，我们检查了 14 种不同的条件，并对 30,000 个具有功能代表性的酵母基因对进行了动态、差异相互作用的评分。不同的条件揭示了新的差异相互作用，这通常揭示了远亲基因对之间的功能联系。然而，大多数观察到的遗传相互作用在不同条件下保持不变，