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Lemierre’s syndrome
Practical Neurology ( IF 2.4 ) Pub Date : 2021-10-01 , DOI: 10.1136/practneurol-2021-002928
Eng Chuan Foo 1 , Matthew Tanti 2 , Helen Cliffe 3 , Marc Randall 2
Affiliation  

Lemierre’s syndrome is a rare and potentially life-threatening condition that follows an oropharyngeal infection, typically from Fusobacterium necrophorum, and usually affects healthy adolescents or young adults. The characteristic features are septic thrombophlebitis of the internal jugular vein and septic embolism leading to multiorgan involvement, commonly the brain, lungs and bones. We report a man with presenting symptoms suggesting hemicrania continua, whose initial imaging showed no features of dural venous sinus or jugular thrombosis. Two weeks later, he had fever, sore throat, cervical lymphadenopathy and Actinomyces meyeri grew from peripheral blood cultures. Further imaging identified thrombosis of the internal jugular vein and cerebral venous sinuses, with multifocal cavitating lung lesions. Following antibiotics and anticoagulation, he recovered without residual deficits. Lemierre’s syndrome when recognised and treated early has a good prognosis but delayed treatment may result in significant morbidity or mortality.

中文翻译:

勒米埃综合征

Lemierre 综合征是一种罕见且可能危及生命的疾病,它发生在口咽感染后,通常来自死叉梭杆菌,通常会影响健康的青少年或年轻人。特征是颈内静脉脓毒性血栓性静脉炎和脓毒性栓塞导致多器官受累,通常累及脑、肺和骨骼。我们报告了一名男子,其表现出的症状提示为连续性偏头痛,其初始影像学显示没有硬脑膜静脉窦或颈静脉血栓形成的特征。两周后,他发烧、喉咙痛、颈部淋巴结肿大,外周血培养物生长出迈耶放线菌。进一步的影像学发现颈内静脉和脑静脉窦血栓形成,并伴有多灶性空洞性肺病变。继抗生素和抗凝治疗后,他康复了,没有剩余的赤字。Lemierre 综合征在早期识别和治疗时预后良好,但延迟治疗可能导致显着的发病率或死亡率。
更新日期:2021-09-17
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