Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women,Gut

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Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women
Gut ( IF 23.0 ) Pub Date : 2021-12-01 , DOI: 10.1136/gutjnl-2020-323450
Jinhee Hur ₁ , Ebunoluwa Otegbeye _{2,

3} , Hee-Kyung Joh _{1,

4} , Katharina Nimptsch _{1,

5} , Kimmie Ng ₆ , Shuji Ogino _{7,

8,

9} , Jeffrey A Meyerhardt ₆ , Andrew T Chan _{9,

10,

11,

12,

13} , Walter C Willett _{1,

8,

12} , Kana Wu ₁ , Edward Giovannucci _{1,

8,

12} , Yin Cao _{14,

15,

16}

Affiliation

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Department of Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Objective Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined. Design In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake in adulthood and adolescence with EO-CRC risk among 95 464 women who had reported adulthood beverage intake using validated food frequency questionnaires (FFQs) every 4 years. A subset of 41 272 participants reported beverage intake at age 13–18 years using a validated high school-FFQ in 1998. Cox proportional hazards models were used to estimate relative risks (RRs) with 95% CIs. Results We documented 109 EO-CRC cases. Compared with individuals who consumed <1 serving/week of SSBs in adulthood, women who consumed ≥2 servings/day had a more than doubled risk of EO-CRC (RR 2.18; 95% CI 1.10 to 4.35; ptrend=0.02), with a 16% higher risk (RR 1.16; 95% CI 1.00 to 1.36) per serving/day increase. Each serving/day increment of SSB intake at age 13–18 years was associated with a 32% higher risk of EO-CRC (RR 1.32; 95% CI 1.00 to 1.75). Replacing each serving/day of adulthood SSB intake with that of artificially sweetened beverages, coffee, reduced fat milk or total milk was associated with a 17%–36% lower risk of EO-CRC. Conclusion Higher SSB intake in adulthood and adolescence was associated with a higher risk of EO-CRC among women. Reduction of SSB consumption among adolescents and young adults may serve as a potential strategy to alleviate the growing burden of EO-CRC. No additional data are available.

中文翻译：

成年期和青春期含糖饮料摄入量与女性早发性结直肠癌的风险

目标直到 2000 年，美国出生队列中的含糖饮料 (SSB) 消费量大幅增加，其中 50 岁以下的青少年和年轻人的消费量最高。然而，SSB 与早发性结直肠癌 (EO-CRC) 之间的联系仍未得到检验。设计在护士健康研究 II (1991-2015) 中，我们前瞻性地调查了 95 464 名女性在成年和青春期 SSB 摄入量与 EO-CRC 风险之间的关系，这些女性使用经过验证的食物频率问卷 (FFQ) 报告成年期饮料摄入量。 4年。 1998 年，41 272 名参与者使用经验证的高中 FFQ 报告了 13-18 岁的饮料摄入量。Cox 比例风险模型用于估计 95% CI 的相对风险 (RR)。结果我们记录了 109 例 EO-CRC 病例。与成年后每周摄入 <1 份 SSB 的个体相比，每天摄入 ≥2 份 SSB 的女性患 EO-CRC 的风险增加一倍以上（RR 2.18；95% CI 1.10 至 4.35；ptrend=0.02），每增加一份服务/天，风险就会增加 16%（RR 1.16；95% CI 1.00 至 1.36）。 13-18 岁时，SSB 摄入量每增加一份/天，患 EO-CRC 的风险就会增加 32%（RR 1.32；95% CI 1.00 至 1.75）。用人工甜味剂饮料、咖啡、低脂牛奶或全脂牛奶代替成年期每份 SSB 摄入量，可使 EO-CRC 风险降低 17%–36%。结论女性成年期和青春期 SSB 摄入量较高与 EO-CRC 风险较高相关。减少青少年和年轻人的 SSB 消费可能是减轻 EO-CRC 日益增长的负担的潜在策略。没有其他可用数据。

更新日期：2021-11-08

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