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The Sliding Filament Theory Since Andrew Huxley: Multiscale and Multidisciplinary Muscle Research
Annual Review of Biophysics ( IF 10.4 ) Pub Date : 2021-05-06 , DOI: 10.1146/annurev-biophys-110320-062613
Joseph D Powers 1 , Sage A Malingen 2 , Michael Regnier 3, 4 , Thomas L Daniel 2, 3, 4
Affiliation  

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of muscle contraction based on force-generating interactions between myofilaments in the sarcomere that cause filaments to slide past one another during muscle contraction. The succeeding decades of research in muscle physiology have revealed a unifying interest: to understand the multiscale processes—from atom to organ—that govern muscle function. Such an understanding would have profound consequences for a vast array of applications, from developing new biomimetic technologies to treating heart disease. However, connecting structural and functional properties that are relevant at one spatiotemporal scale to those that are relevant at other scales remains a great challenge. Through a lens of multiscale dynamics, we review in this article current and historical research in muscle physiology sparked by the sliding filament theory.

中文翻译:



自安德鲁·赫胥黎以来的滑动丝理论:多尺度和多学科的肌肉研究



1954 年发表的两篇开创性论文提出了肌肉收缩机制的理论,该理论基于肌节中肌丝之间产生力的相互作用,这种相互作用导致肌丝在肌肉收缩过程中相互滑过。接下来几十年的肌肉生理学研究揭示了一个统一的兴趣:了解控制肌肉功能的多尺度过程(从原子到器官)。这种理解将对从开发新的仿生技术到治疗心脏病等广泛的应用产生深远的影响。然而,将一个时空尺度上相关的结构和功能特性与其他尺度上相关的结构和功能特性联系起来仍然是一个巨大的挑战。通过多尺度动力学的视角,我们在本文中回顾了由滑动丝理论引发的肌肉生理学的当前和历史研究。

更新日期:2021-05-07
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