Background

The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance. Furthermore, 2-pyridones are a different category of pharmacophores that exhibit several biological activities. Results: The 2-pyridones substrates are synthetically multilateral, where they can be used to synthesize a wide range of heterocyclic compounds and as a drug synthesis raw material. Therefore, it was the purpose of this review to evaluate the pharmacological properties of various substituted 2-pyridone systematically and collates these findings to be used as a guide for future structure–activity relationship and mode of action studies. Conclusion: Taken together, we demonstrate that the fused 2-pyridone is a versatile scaffold for biological applications.

中文翻译：

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2-吡啶酮支架的化学和药理学方面的最新进展

背景

2-吡啶酮结构的化学和应用近来由于其用作合成中间体的用途及其生物学重要性而引起了广泛的关注。此外，2-吡啶酮是展示几种生物学活性的药效基团的不同类别。结果：2-吡啶酮底物在合成上是多边的，可用于合成多种杂环化合物并用作药物合成原料。因此，本综述的目的是系统地评估各种取代的2-吡啶酮的药理特性，并整理这些发现，以用作将来结构-活性关系和作用方式研究的指南。结论：综上所述，我们证明了融合的2-吡啶酮是用于生物学应用的通用支架。