Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ multiple mechanisms to avoid immune recognition and suppress antitumor immune responses. Recently, accumulating evidence has indicated that immune-related pathways are epigenetically dysregulated in cancer. Most importantly, the epigenetic footprint of immune-related pathways is associated with the patient outcome, underscoring the crucial need to understand this process. In this review, we summarize the current evidence for epigenetic regulation of immune-related pathways in cancer and describe bioinformatics tools, informative visualization techniques, and resources to help decipher the cancer epigenome.

癌症免疫逃避是致癌的标志之一。癌细胞采用多种机制来避免免疫识别并抑制抗肿瘤免疫反应。最近，越来越多的证据表明，免疫相关通路在癌症中表观遗传失调。最重要的是，免疫相关通路的表观遗传足迹与患者预后相关，强调了理解这一过程的关键需求。在这篇综述中，我们总结了目前癌症中免疫相关通路表观遗传调控的证据，并描述了生物信息学工具、信息可视化技术和有助于破译癌症表观基因组的资源。