Abstract

MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). The cognitive mechanisms of “how” MBSR(BC) works was addressed in a recent study that found that there was strong consistent evidence that reduced emotional reactivity is a mediator and moderate consistent evidence that mindfulness, rumination, and worry were mediators. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased fear of breast cancer recurrence, and perceived stress. Female BCS > 21 years diagnosed with Stage 0-III breast cancer were randomly assigned to a 6-week MBSR(BC) or a Usual Care (UC)regimen. Potential mediators of 6- and 12-week outcomes were identified by analysis of covariance (ANCOVA), followed by formal mediational analyses of main effects of MBSR(BC) on 6- and 12-week outcomes, including percentage of total effects explained. Among 322 BCS (167 MBSR(BC) and 155 UC), fear of recurrence and perceived stress, but not mindfulness, mediated reductions in anxiety and fatigue at weeks 6 and 12, partially supporting our hypothesis of cognitive mechanisms of MBSR(BC).

Trial Registration

Registration Number: NCT01177124 http://www.ClinicalTrials.gov

中文翻译：

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乳腺癌幸存者基于正念的压力减轻 (MBSR(BC))：在大型随机对照试验中评估心理和身体结果的中介因素

摘要

众所周知，MBSR(BC) 对乳腺癌幸存者 (BCS) 的心理和身体症状有积极影响。MBSR（BC）“如何”工作的认知机制在最近的一项研究中得到了解决，该研究发现，有强烈一致的证据表明情绪反应减少是一种中介，而适度一致的证据表明正念、沉思和担忧是中介。作为更大的 R01 试验的一部分，这项研究的目的是测试 MBSR(BC) 计划所取得的积极影响是否通过提高正念、减少对乳腺癌复发的恐惧和感知压力的变化来调节。被诊断患有 0-III 期乳腺癌的女性 BCS > 21 岁被随机分配到 6 周的 MBSR(BC) 或常规护理 (UC) 方案。通过协方差分析 (ANCOVA) 确定了 6 周和 12 周结果的潜在中介因素，然后对 MBSR(BC) 对 6 周和 12 周结果的主要影响进行了正式的中介分析，包括解释的总影响的百分比。在 322 BCS（167 MBSR（BC）和 155 UC）中，对复发的恐惧和感知压力，但不是正念，介导了第 6 周和第 12 周的焦虑和疲劳减少，部分支持了我们关于 MBSR（BC）认知机制的假设。

试用注册

注册号：NCT01177124 http://www.ClinicalTrials.gov