The year 2020 occupies a special significance in the history of the world. We all have lived through this surreal year as the Covid-19 pandemic, named unusually for the year when it struck the world, shut the entire world for a while and shook every individual directly or indirectly. Surprisingly, the show has gone on. We all have responded positively. The technology has bridged the gap between individuals even as social distancing was practised. The world produced food, made medicines, and conducted its business, albeit not as usual. And vaccines for SARS-CoV2 are also on the horizon. Our own Institution, IISc, responded to the pandemic well. It took care of its students when they returned to the campus in batches. It took care of the staff and faculty, and their families. Even though experimental work in the laboratories has been affected badly, the rest of the work has gone on. Our classes swiftly turned to the online mode. We conducted our interviews for research students online. The new students began their first semester online without stepping into the campus. Publications, patents, online symposia, and other research activities continued unhindered. Most importantly, IISc responded with timely innovations on several fronts: diagnostics and surveillance, modeling and simulation of the spread of Covid-19, ventilators and oxygenators of various kinds, and also vaccine development. After all, it feels as though everything in 2020 went on like clockwork in a well-oiled machine despite the challenges posed by the pandemic. A well-orchestrated machine indeed has this uncanny ability to respond to disturbances. Talking of a machine, some consider a single biological cell a machine. That is probably why we talk of cell mechanics. Cell’s machinery comprises G. Ananthasuresh* J. Indian Inst. Sci.

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2020年在世界历史上具有特殊意义。我们都度过了这个超现实的一年，因为 Covid-19 大流行以不同寻常的名字命名，因为它袭击了世界，让整个世界暂时关闭，并直接或间接地震撼了每个人。出人意料的是，节目还在继续。我们都做出了积极的回应。即使实行了社会疏离，该技术也弥合了人与人之间的差距。世界生产食品、制造药品并开展业务，尽管与往常不同。SARS-CoV2 的疫苗也即将问世。我们自己的机构 IISc 很好地应对了这一流行病。学生分批返校时照顾。它照顾了教职员工和他们的家人。尽管实验室的实验工作受到了严重影响，剩下的工作还在继续。我们的课堂迅速转向在线模式。我们在网上对研究生进行了采访。新生们在没有踏入校园的情况下就在网上开始了他们的第一学期。出版物、专利、在线研讨会和其他研究活动继续畅通无阻。最重要的是，IISc 在几个方面做出了及时的创新：诊断和监测、Covid-19 传播的建模和模拟、各种呼吸机和氧合器，以及疫苗开发。毕竟，尽管大流行带来了挑战，但感觉好像 2020 年的一切都像运转良好的机器中的发条一样继续进行。精心编排的机器确实具有这种对干扰做出反应的不可思议的能力。谈到机器，有些人认为单个生物细胞就是机器。这可能就是我们谈论细胞力学的原因。Cell 的机器包括 G. Ananthasuresh* J. Indian Inst。科学。