Abstract

Since regenerating islet-derived 3β (Reg3β) was first reported, various studies have been conducted to explore the involvement of Reg3β in a gamut of maladies, such as diabetes, pancreatitis, pancreatic ductal adenocarcinoma, and extrapancreatic maladies such as inflammatory bowel disease, acute liver failure, and myocardial infarction. Surprisingly, there is currently no systematic review of Reg3β. Therefore, we summarize the structural characteristics, transcriptional regulation, putative receptors, and signaling pathways of Reg3β. The exact functional roles in various diseases, especially gastrointestinal and liver diseases, are also discussed. Reg3β plays multiple roles in promoting proliferation, inducing differentiation, preventing apoptosis, and resisting bacteria. The present review may provide new directions for the diagnosis and treatment of gastrointestinal, liver, and pancreatic diseases.

摘要

自从首次报道了再生胰岛衍生的 3β (Reg3β) 以来，已经进行了各种研究来探索 Reg3β 在一系列疾病中的作用，例如糖尿病、胰腺炎、胰腺导管腺癌和胰腺外疾病，例如炎症性肠病、急性肝功能衰竭和心肌梗塞。令人惊讶的是，目前还没有关于 Reg3β 的系统评价。因此，我们总结了Reg3β的结构特征、转录调控、推定受体和信号通路。还讨论了在各种疾病，特别是胃肠道和肝脏疾病中的确切功能作用。Reg3β在促进增殖、诱导分化、防止细胞凋亡和抗细菌方面发挥多重作用。