The present investigation aims for the synthesis of copper oxide nanoparticles (CuO NPs) using Nilgirianthus ciliatus plant extract. The obtained CuO NPs were characterised by X-ray diffraction, Fourier transform infrared spectrum, ultraviolet-visible spectroscopy, photoluminescence, scanning electron microscopy and transmission electron microscopy analysis. Significant bacterial activity was manifested by CuO nanoparticles against both Gram-positive (Staphylococcus aureus and Staphylococcus mutans) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. The synthesised CuO NPs have good cytotoxicity against both human breast cancer cell line (MCF-7) and lung cancer cell line (A549) with minimum cytotoxic effect on normal L929 (fibroblast) cell lines.

中文翻译：

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生物合成的CuO纳米粒子的抗菌和抗癌活性。

本研究旨在使用 Nilgirithus ciliatus 植物提取物合成氧化铜纳米颗粒 (CuO NPs)。通过X射线衍射、傅里叶变换红外光谱、紫外-可见光谱、光致发光、扫描电子显微镜和透射电子显微镜分析对所获得的CuO NPs进行了表征。CuO 纳米颗粒对革兰氏阳性菌（金黄色葡萄球菌和变形葡萄球菌）和革兰氏阴性菌（大肠杆菌和铜绿假单胞菌）均表现出显着的细菌活性。合成的 CuO NPs 对人乳腺癌细胞系 (MCF-7) 和肺癌细胞系 (A549) 均具有良好的细胞毒性，对正常 L929 (成纤维细胞) 细胞系的细胞毒性作用最小。