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Synthesis of manganese doped β-FeOOH and MnFe2O4 nanorods for enhanced drug delivery and hyperthermia application.
IET Nanobiotechnology ( IF 3.8 ) Pub Date : 2020-12-01 , DOI: 10.1049/iet-nbt.2020.0098
Chandunika R K 1 , Vijayaraghavan Rajagopalan 2 , Niroj Kumar Sahu 1
Affiliation  

Preparation of manganese ferrite (MnFe2O4) nanorods by the reduction of akaganeite seeds in the presence of oleylamine is reported. The Mn-doped β-FeOOH akaganeite seeds have been processed by the hydrolysis of metal-chloride salts in the presence of polyethylenimine (PEI) surfactant. The hydrophobic oleylamine capped nanorods are made hydrophilic using trisodium citrate as a phase transferring agent. The nanorods form with an aspect ratio of 5.47 and possess a high magnetisation value of 69 emu/g at an applied magnetic field of 1.5 T. The colloidal water dispersion of nanorods exhibits superior heating efficiency by the application of alternating magnetic field (AMF). A specific absorption rate value of 798 W/g is achieved at an applied AMF of field strength 500 Oe and frequency 316 kHz. Further, the citrate functionalised nanorods are capable of attaching with doxorubicin (DOX) electrostatically with a loading efficiency of 97% and the drug release is pH responsive. The DOX loaded nanorods show a promising effect on the apoptosis of MCF-7 as experimented in vitro.

中文翻译:


合成锰掺杂 β-FeOOH 和 MnFe2O4 纳米棒,用于增强药物输送和热疗应用。



据报道,通过在油胺存在下还原 akaganeite 晶种来制备铁酸锰 (MnFe2O4) 纳米棒。在聚乙烯亚胺 (PEI) 表面活性剂存在下,通过金属氯化物盐的水解处理锰掺杂的 β-FeOOH 赤铜矿种子。使用柠檬酸三钠作为相转移剂使疏水性油胺封端的纳米棒具有亲水性。纳米棒的长宽比为 5.47,在 1.5 T 的外加磁场下具有 69 emu/g 的高磁化强度。通过应用交变磁场 (AMF),纳米棒的胶体水分散体表现出优异的加热效率。在施加场强 500 Oe 和频率 316 kHz 的 AMF 时,可实现 798 W/g 的比吸收率值。此外,柠檬酸盐功能化的纳米棒能够静电附着阿霉素(DOX),负载效率为97%,并且药物释放具有pH响应性。体外实验显示,负载 DOX 的纳米棒对 MCF-7 细胞凋亡具有良好的作用。
更新日期:2020-12-01
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