The therapeutics for type 2 diabetes mellitus has emerged in the current century towards nanomedicine incorporated with plant active compounds. In this study, Tinospora cordifolia loaded poly (D, L-lactide) (PLA) nanoparticles (NPs) were evaluated in vivo for their anti-hyperglycemic potency towards streptozotocin-induced type 2 diabetic rats. T. cordifolia loaded PLA NPs were synthesised by the double solvent evaporation method using PLA polymer. The NPs were then characterised and administrated orally for 28 successive days to streptozotocin-induced diabetic rats. The PLA NPs had significant anti-diabetic effects which were equal to the existing anti-diabetic drug glibenclamide. The antidiabetic activity is due to the synergism of compounds present in stem extract of the plant which reduced the side effects and anti-diabetic.

中文翻译：

---

使用聚（D，L-丙交酯）纳米颗粒的纳米胶囊心叶青牛胆（Tinospora cordifolia，Willd.）可有效控制链脲佐菌素诱导的 2 型糖尿病大鼠。


本世纪出现的 2 型糖尿病治疗方法是结合植物活性化合物的纳米药物。在这项研究中，在体内评估了心叶青牛胆负载的聚（D，L-丙交酯）（PLA）纳米颗粒（NP）对链脲佐菌素诱导的 2 型糖尿病大鼠的抗高血糖功效。采用PLA聚合物通过双溶剂蒸发法合成了负载T. cordifolia的PLA NPs。然后对这些 NP 进行表征，并连续 28 天给链脲佐菌素诱导的糖尿病大鼠口服给药。 PLA NPs具有显着的抗糖尿病作用，与现有抗糖尿病药物格列本脲相当。抗糖尿病活性是由于植物茎提取物中存在的化合物的协同作用，减少了副作用并具有抗糖尿病作用。