In this report, the site-specific co-delivery of green tea/aluminium magnesium silicate (AMS) was reported and the specific target delivery was achieved orally. The new co-precipitation process was developed to synthesis the green tea/AMS hybrid complex and using energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy and Raman confirmed its successful synthesis. The blood biocompatibility of the green tea/AMS was tested using chicken blood, and the compound is safe up to 500 mg/ml. After mixed with hydroxypropyl methylcellulose phthalate, the oral beads were synthesised using a linking agent. The oral beads underwent different pH-based dissolution studies and the results indicated that the beads specifically dissolved in gastric pH (6.5). The pharmaco kinetic studies were performed to estimate the delivery kinetics. The results revealed that the beads underwent as per the Higuchi model. The anticoccidial effects of the beads were tested using chicken. The animal studies were performed in two different modes such as prophylactic treatment and active treatment after Eimeria species challenge. The results indicated that the prophylactic treatment with beads 100% protected the chicken and the active treatment with beads after the Eimeria challenge significantly protected against the intestinal damage and it also enhanced the anticoccidial effect.

中文翻译：

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绿茶包覆的硅酸铝镁珠的特定部位递送及其对鸡球虫病的影响研究。

在本报告中，报告了绿茶/硅酸铝镁（AMS）的特定地点共同交付，并通过口服实现了特定目标交付。开发了新的共沉淀工艺来合成绿茶/AMS 杂化复合物，并使用能量色散 X 射线光谱、傅里叶变换红外光谱和拉曼证实了其成功合成。绿茶/AMS 的血液生物相容性是用鸡血测试的，该化合物在高达 500 mg/ml 的浓度下是安全的。与羟丙基甲基纤维素邻苯二甲酸酯混合后，使用连接剂合成口腔珠。口服珠子经历了不同的基于 pH 值的溶出度研究，结果表明珠子特异性地溶解在胃部 pH 值（6.5）中。进行药代动力学研究以估计递送动力学。结果显示，珠子按照 Higuchi 模型进行。使用鸡肉测试珠子的抗球虫作用。动物研究以两种不同的模式进行，例如艾美球虫属物种攻击后的预防性治疗和主动治疗。结果表明，用珠子进行预防性处理100%保护鸡，在艾美球虫攻击后用珠子主动处理可显着保护肠道免受损伤，并且还增强了抗球虫作用。