The complement component 1, q subcomponent binding protein (C1QBP/gC1q-R/p32/HABP1/TAP/YBAP1), is a ubiquitous, multifunctional protein. C1QBP localizes mainly to mitochondria due to its N-terminal mitochondrial localization signal, but it can also be found in different subcellular compartments including the cell surface, nucleus, cytoplasm, and extracellular space. C1QBP has been reported to interact with a variety of proteins that have apparently unrelated functions. C1QBP has also been observed to interact with hyaluronic acid and RNA. These findings suggest that C1QBP has both mitochondrial and extramitochondrial functions. The C1QBP binding sites of many partner proteins are located within basic and intrinsically disordered regions of these molecules, consistent with the hypothesis that C1QBP functions as a molecular chaperone. C1QBP expression is elevated in various types of human cancers, including breast cancer. Moreover, it has been implicated in the development, progression, and metastasis of cancer cells based on loss-of-function and gain-of-function studies using cancer cell lines and xenograft models. Hence C1QBP could be a molecular target in breast cancer therapy. Studies using antibodies, tumor homing peptides such as LyP-1, and small molecules that target C1QBP warrant further investigation as C1QBP is a potential therapeutic target.

补体成分 1，q 亚成分结合蛋白 (C1QBP/gC1q-R/p32/HABP1/TAP/YBAP1)，是一种无处不在的多功能蛋白质。由于其 N 端线粒体定位信号，C1QBP 主要定位于线粒体，但也可以在不同的亚细胞区室中找到，包括细胞表面、细胞核、细胞质和细胞外空间。据报道，C1QBP 与多种具有明显无关功能的蛋白质相互作用。还观察到 C1QBP 与透明质酸和 RNA 相互作用。这些发现表明 C1QBP 具有线粒体和线粒体外功能。许多伙伴蛋白的 C1QBP 结合位点位于这些分子的基本和内在无序区域内，这与 C1QBP 作为分子伴侣发挥作用的假设一致。C1QBP 表达在各种类型的人类癌症中升高，包括乳腺癌。此外，基于使用癌细胞系和异种移植模型的功能丧失和功能获得研究，它与癌细胞的发育、进展和转移有关。因此，C1QBP 可能是乳腺癌治疗的分子靶点。使用抗体、肿瘤归巢肽（如 LyP-1）和靶向 C1QBP 的小分子的研究值得进一步研究，因为 C1QBP 是一个潜在的治疗靶点。因此，C1QBP 可能是乳腺癌治疗的分子靶点。使用抗体、肿瘤归巢肽（如 LyP-1）和靶向 C1QBP 的小分子的研究值得进一步研究，因为 C1QBP 是一个潜在的治疗靶点。因此，C1QBP 可能是乳腺癌治疗的分子靶点。使用抗体、肿瘤归巢肽（如 LyP-1）和靶向 C1QBP 的小分子的研究值得进一步研究，因为 C1QBP 是一个潜在的治疗靶点。