Breast cancer is the most common malignant tumor in women worldwide. Traditional ways of treatment, including radiotherapy and endocrine therapy, for breast cancer have inevitable side effects. In recent decades, targeted therapies for breast cancer have rapidly advanced and shown a promising future. The JAK/STAT signaling pathway has been shown to play important roles in tumorigenesis, maintenance and metastasis of breast cancer. Hence, many small molecule inhibitors of JAK and STAT proteins have been developed. These inhibitors exhibit potent inhibitory effects on breast cancer in both cellular and animal models, and even some of them have already been in clinical trials. This review article discussed the JAK/STAT signal transduction pathway in the pathogenesis of breast cancer, and the potential for the application of JAK/STAT inhibitors in breast cancer treatment.

乳腺癌是全球女性最常见的恶性肿瘤。传统的乳腺癌治疗方法，包括放疗和内分泌治疗，不可避免地会产生副作用。近几十年来，针对乳腺癌的靶向治疗取得了迅速的进展，并显示出充满希望的未来。JAK/STAT 信号通路已被证明在乳腺癌的肿瘤发生、维持和转移中发挥重要作用。因此，已经开发了许多 JAK 和 STAT 蛋白的小分子抑制剂。这些抑制剂在细胞和动物模型中都表现出对乳腺癌的有效抑制作用，甚至其中一些已经进入临床试验。这篇综述文章讨论了 JAK/STAT 信号转导通路在乳腺癌发病机制中的作用，