This study assessed the solute permeability of a family of UV and moisture cured acrylates-based adhesives during in vitro ageing in pH 7.4 buffer. Acrylates have a potential role in bone fracture fixation, but their inability to allow microsolute exchange between the fractured bone surfaces may contribute to ineffective healing. Cyclic voltammetry and chronoamperometry were used to determine the diffusion coefficients for various electrochemically active probe molecules (O2, H2O2, acetaminophen, catechol, uric acid and ascorbic acid) at proprietary acrylic, urethane – acrylate and cyanoacrylate adhesives. All adhesives proved to be impermeable for up to 9 days ageing, following which a near-exponential increase in permeability resulted for all solutes. At 18 days, the diffusion coefficients were in the range of 10−5 cm2s−1 for O2 and H2O2 and 10−6 cm2s−1 for the organic solutes; no transport selectivity was seen between the latter. Adhesive joint strength showed a direct, inverse, correlation with permeability, with the more hydrophilic cyanoacrylates showing the greatest loss of strength. Adhesive permeabilisation does not appear to be compatible with the retention of bonding strength, but it serves as a new non-destructive predictor of adhesion strength change during ageing and practical use.

中文翻译：

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体外老化过程中丙烯酸酯骨粘合剂渗透性和选择性变化的电化学研究：生物材料和膜屏障研究的模型方法

本研究评估了在 pH 7.4 缓冲液中体外老化过程中一系列紫外线和湿气固化丙烯酸酯粘合剂的溶质渗透性。丙烯酸酯在骨折固定中具有潜在作用，但它们不能允许骨折骨表面之间的微溶质交换可能导致无效愈合。循环伏安法和计时电流法用于确定各种电化学活性探针分子（O2、H2O2、对乙酰氨基酚、儿茶酚、尿酸和抗坏血酸）在专有丙烯酸、聚氨酯-丙烯酸酯和氰基丙烯酸酯粘合剂中的扩散系数。所有胶粘剂都被证明在长达 9 天的老化过程中是不渗透的，随后所有溶质的渗透性几乎呈指数增长。18天时，O2 和 H2O2 的扩散系数在 10-5 cm2s-1 范围内，有机溶质的扩散系数在 10-6 cm2s-1 范围内；后者之间没有观察到运输选择性。粘合接头强度与渗透性呈正相关、反比关系，亲水性更强的氰基丙烯酸酯的强度损失最大。粘合剂渗透似乎与保持粘合强度不相容，但它可以作为老化和实际使用过程中粘合强度变化的新的非破坏性预测指标。