The importance of sun exposure on human health is well recognized, and a recent trend in the avoidance of sun exposure has led to the risk of missing the beneficial effects such as vitamin D₃ biogenesis. Vitamin D₃ insufficiency is one of the risk factors for the development of food allergies (FAs), and vitamin D₃ status controls gut homeostasis by modulating the microbiota. This study aimed to explore the impact of daily full spectrum light exposure (phototherapy) on the pathogenesis of FAs. Phototherapy ameliorated allergic diarrhea and improved FA-associated vitamin D₃ insufficiency and dysbiosis. Fecal microbiota transplantation (FMT) of FA donor feces induced allergic diarrhea with OVA-specific IgE elevation in naïve mice. In contrast, FMT of naïve donor feces ameliorated allergic diarrhea in established FA mice, suggesting the involvement of the microbiota composition in FA. Phototherapy is an alternative approach for the prevention of FA-like allergic diarrhea through the modulation of vitamin D₃ status and microbiota composition.

日晒对人类健康的重要性已得到广泛认可，最近避免日晒的趋势已导致错过维生素 D ₃生物合成等有益作用的风险。维生素 D ₃不足是发生食物过敏 (FA) 的危险因素之一，维生素 D ₃状态通过调节微生物群来控制肠道稳态。本研究旨在探讨每日全光谱光照（光疗）对 FA 发病机制的影响。光疗可改善过敏性腹泻并改善 FA 相关维生素 D ₃不足和生态失调。FA 供体粪便的粪便微生物群移植 (FMT) 在幼稚小鼠中诱导过敏性腹泻，并伴有 OVA 特异性 IgE 升高。相比之下，原始供体粪便的 FMT 改善了已建立的 FA 小鼠的过敏性腹泻，表明微生物群组成参与了 FA。光疗是一种通过调节维生素 D ₃状态和微生物群组成来预防 FA 样过敏性腹泻的替代方法。