Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation,STEM CELLS Translational Medicine

当前位置： X-MOL 学术 › Stem Cells Transl. Med. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation
STEM CELLS Translational Medicine ( IF 5.4 ) Pub Date : 2021-05-05 , DOI: 10.1002/sctm.20-0408
Vivek Singh ₁ , Anil Tiwari _{2,

3} , Abhinav Reddy Kethiri ₁ , Virender Singh Sangwan ₃

Affiliation

Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.

中文翻译：

角膜缘干细胞研究现状及其在眼表再生和角膜缘干细胞移植中的应用

角膜缘干细胞参与补充和维持角膜上皮。由于化学/物理损伤、感染或遗传性疾病导致角膜缘损伤，导致角膜缘干细胞缺乏症 (LSCD)，导致部分或全部视力丧失。目前，LSCD 的治疗方法是移植来自受者、亲属或尸体捐赠者的健康眼睛的角膜缘干细胞。这篇综述讨论了角膜缘干细胞、细胞外基质在干细胞生态位维持中的重要性、治疗 LSCD 的历史观点，包括相关的优点和局限性，以及我们几十年来角膜缘干细胞移植的经验。

更新日期：2021-05-05

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11