Increased morbidity and mortality of candidiasis are a notable threat to the immunocompromised patients. At present, the types of drugs available to treat C. albicans infection are relatively limited. Moreover, the emergence of antifungal drug resistance of C. albicans makes the treatment of C. albicans infection more difficult. The calcium-calcineurin signaling pathway plays a crucial role in the survival and pathogenicity of C. albicans and may act as a potential target against C. albicans. In this review, we summarized functions of the calcium-calcineurin signaling pathway in several biological processes, compared the differences of this signaling pathway between C. albicans and humans, and described anti-C. albicans activity of inhibitors of this signaling pathway. We believe that targeting the calcium-calcineurin signaling pathway is a promising strategy to cope with C. albicans infection.

念珠菌病的发病率和死亡率增加是对免疫功能低下患者的显着威胁。目前，可用于治疗白色念珠菌感染的药物种类相对有限。而且，白色念珠菌抗真菌药物耐药性的出现，使得白色念珠菌感染的治疗更加困难。钙调神经磷酸酶信号通路在白色念珠菌的存活和致病性中起着至关重要的作用，并且可能作为对抗白色念珠菌的潜在靶标。在这篇综述中，我们总结了钙调神经磷酸酶信号通路在几个生物过程中的功能，比较了该信号通路在白色念珠菌之间的差异和人类，并描述了该信号通路抑制剂的抗白色念珠菌活性。我们认为，靶向钙-钙调神经磷酸酶信号通路是应对白色念珠菌感染的一种很有前景的策略。