Patients with cancer tend to have an increased risk of sleep disorders. The exact association between cancer and sleep disorders remains uncertain. We aimed to investigate whether elevated perceived stress is linked to a higher risk of sleep disorders in patients with and without cancer history respectively. A total of 941 adult individuals from the Midlife in the United States (MIDUS) study were included in this study. Multivariate analyses were used for assessing the association between Perceived Stress Scale (PSS) and Global Pittsburgh Sleep Quality Index (PSQI) Score. Adjusted for age, gender, BMI, blood pressure (BP), smoking and drinking status, exercise, disease history, and blood biomarkers, elevated PSS score was significantly associated with a higher PSQI score in the linear regression model (0.189 [0.154–0.224], p < 0.001; Model 2). The higher PSS score was still significantly associated with Poor sleep status (score > 5) in the logistic regression model (1.062 [1.036–1.090], p < 0.001; Model 2). Stratified analysis showed that the association between PSS and poor sleep status was affected by hypnotics use, but not by ever cancer history. Elevated PSS is linked with a higher risk of poor sleep status in the adult population from the United States. Elevated PSS might mediate the association of cancer and poor sleep quality. Future studies need to evaluate whether reducing PSS can improve sleep status in patients with cancer history.

癌症患者倾向于增加睡眠障碍的风险。癌症与睡眠障碍之间的确切关联仍不确定。我们的目的是研究在患有和无癌症病史的患者中，感知压力的升高是否与睡眠障碍的较高风险相关。这项研究包括来自美国中年（MIDUS）研究的941名成年个体。多变量分析用于评估知觉压力量表（PSS）和全球匹兹堡睡眠质量指数（PSQI）得分之间的关​​联。在对年龄，性别，BMI，血压（BP），吸烟和饮酒状况，运动，疾病史以及血液生物标志物进行校正后，线性回归模型中升高的PSS得分与较高的PSQI得分显着相关（0.189 [0.154-0.224 ]，p  <0.001；模型2）。在Logistic回归模型中，较高的PSS分数仍与睡眠状况差（得分> 5）显着相关（1.062 [1.036-1.090]，p  <0.001；模型2）。分层分析显示，催眠药的使用会影响PSS与不良睡眠状态之间的关联，而不受癌症史的影响。PSS升高与美国成年人口睡眠状况差的较高风险相关。PSS升高可能会介导癌症和睡眠质量差的关联。未来的研究需要评估降低PSS是否可以改善患有癌症病史的患者的睡眠状态。