Flutamide is a man-made non-steroidal anti-androgen drug that is extensively used for the prostate cancer therapy. Though the drug has a higher benefit ratio in treating cancer, it also exhibits certain lethal side effects to humans. It acts as an environmental pollutant instigating water pollution and aquatic organism damage by interfering in their reproductive cycle and its effect on aquatic life is a major concern. Hence, it is mandatory to detect the presence of this nitro-aromatic compound. For the effective determination of this analyte, gold modified Polyhedral Oligomeric Silsesquioxane (abbreviated as POSS-S-Au) based organic-inorganic hybrid material as chemical modifier has been used. This material synthesized via a hydrolysis-condensation reaction technique followed by a phase transfer method is utilized for the first time in the electrochemical determination of anti-cancer drug. The as-synthesized nanomaterial has been subjected to various Physio-chemical characterization and the Fourier Transform- Infrared Spectroscopy (FT-IR) spectra confirm the presence of -SH organic group and Si-O-Si stretch. X-ray Photoelectron Spectroscopy (XPS) spectra affirms the presence of silicon, oxygen, gold, and Sulphur owing to the introduction of gold through the thiolation of silicate core. The fabricated sensor showed excellent electro-catalytic activity for detecting flutamide with limit of detection (LOD) of 0.12 μM, and higher sensitivity of around 0.048 μA/μM.

Flutamide是一种人造非甾体类抗雄激素药物，已广泛用于前列腺癌治疗。尽管该药物在治疗癌症方面具有更高的受益率，但它对人类也显示出某些致命的副作用。它作为环境污染物，通过干扰其繁殖周期来减轻水污染和对水生生物的损害，其对水生生物的影响是一个主要问题。因此，必须检测这种硝基芳族化合物的存在。为了有效测定该分析物，已使用了基于金的多面体寡聚倍半硅氧烷（缩写为POSS-S-Au）为基础的有机-无机杂化材料作为化学改性剂。通过水解-缩合反应技术随后通过相转移法合成的这种材料首次用于抗癌药物的电化学测定。合成后的纳米材料已经过各种物理化学表征，傅立叶变换红外光谱（FT-IR）光谱证实了-SH有机基团和Si-O-Si拉伸的存在。X射线光电子能谱（XPS）光谱证实了硅，氧，金和硫的存在，这是由于通过硅酸盐核的硫醇化作用引入了金。制成的传感器显示出出色的电催化活性，可检测氟他胺，检出限（LOD）为0.12μM，灵敏度更高，约为0.048μA/μM。合成后的纳米材料已经过各种物理化学表征，傅立叶变换红外光谱（FT-IR）光谱证实了-SH有机基团和Si-O-Si拉伸的存在。X射线光电子能谱（XPS）光谱证实了硅，氧，金和硫的存在，这是由于通过硅酸盐核的硫醇化作用引入了金。制成的传感器显示出出色的电催化活性，可检测氟他胺，检出限（LOD）为0.12μM，灵敏度更高，约为0.048μA/μM。合成后的纳米材料已经过各种物理化学表征，傅立叶变换红外光谱（FT-IR）光谱证实了-SH有机基团和Si-O-Si拉伸的存在。X射线光电子能谱（XPS）光谱证实了硅，氧，金和硫的存在，这是由于通过硅酸盐核的硫醇化作用引入了金。制成的传感器显示出出色的电催化活性，可检测氟他胺，检出限（LOD）为0.12μM，灵敏度更高，约为0.048μA/μM。金和硫，这是由于通过硅酸盐核的硫醇化作用引入了金。制成的传感器显示出出色的电催化活性，可检测氟他胺，检出限（LOD）为0.12μM，灵敏度更高，约为0.048μA/μM。金和硫，这是因为通过硅酸盐核的硫醇化作用引入了金。制成的传感器显示出出色的电催化活性，可检测氟他胺，检出限（LOD）为0.12μM，灵敏度更高，约为0.048μA/μM。