Motivation for food reinforcers in mouse models of type 2 diabetes was examined in three experiments. In all experiments, physiological measures indicated the presence of type 2 diabetes. In Experiment 1, high-fat fed Swiss TO mice and lean controls showed a preference for high-fat corn oil reinforcers over high-sugar syrup reinforcers in a T-Maze task, but there were no differences between the two groups. In Experiment 2, high-fat fed Swiss TO mice and lean controls responded for corn oil or food pellet reinforcers on progressive ratio schedules. While break point numbers were higher for corn oil than food pellets, and satiation or extinction reduced break points, there were no differences between the groups. In Experiment 3, streptozotocin treatment was used to induce type 2 diabetes in C57Bl/6 j mice that were compared with controls while responding for corn oil or food pellet reinforcers on progressive ratio schedules. While break point numbers were higher for corn oil than food pellets before and after streptozotocin treatment, and satiation or extinction reduced break points, there were no differences between the groups. Parameters for a more complex method of assessment of progressive ratio behaviour derived from Killeen’s Mathematical Principles of Reinforcement were also computed. While the parameter associated with incentive value was higher for corn oil than for food pellets, parameters were not significantly affected by streptozotocin treatment. Overall, a range of behavioural measures of food motivation failed to reveal effects of changes relative to controls in mice that showed physiological evidence of type 2 diabetes.

在三个实验中检查了2型糖尿病小鼠模型中食物强化剂的动机。在所有实验中，生理指标均表明存在2型糖尿病。在实验1中，在T-Maze任务中，高脂喂养的Swiss TO小鼠和瘦肉对照组显示了高脂玉米油增强剂优于高糖糖浆增强剂，但两组之间没有差异。在实验2中，高脂喂养的Swiss TO小鼠和瘦肉对照组对玉米油或食物颗粒增强剂的反应是按比例进行的。尽管玉米油的断点数高于食物颗粒，饱食或消光减少了断点，但两组之间没有差异。在实验3中，链脲佐菌素治疗用于在C57Bl / 6 j小鼠中诱导2型糖尿病，将其与对照组进行比较，同时按渐进比例方案对玉米油或食物颗粒增强剂做出反应。尽管玉米油的断点数高于链脲佐菌素处理前后的食物颗粒，饱食或绝种减少了断点，但两组之间没有差异。还计算了用于评估渐进比率行为的更复杂方法的参数，这些方法源自基林的增强数学原理。尽管玉米油的激励值相关参数高于食品颗粒，但链脲佐菌素处理对参数的影响并不显着。全面的，