Cognitive impairment occurs in approximately 50% of remitted patients with bipolar disorder (BD). However, there exists no treatment with replicated and robust efficacy on cognition in BD. This is partially due to limited insight into the neuronal underpinnings of cognitive impairment in these patients. This is the first study to investigate neuronal underpinnings of cognitive impairment in a large functional magnetic resonance imaging (fMRI) dataset comparing neural activity patterns between distinct neurocognitive subgroups of partially or fully remitted patients with BD.

中文翻译：

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双相情感障碍认知障碍的神经元基础：一项大数据驱动的功能磁共振成像研究

大约 50% 的双相情感障碍 (BD) 缓解患者出现认知障碍。然而，没有对 BD 的认知具有重复和强大功效的治疗方法。这部分是由于对这些患者认知障碍的神经元基础的了解有限。这是第一项在大型功能磁共振成像 (fMRI) 数据集中研究认知障碍的神经元基础的研究，比较了部分或完全缓解的 BD 患者的不同神经认知亚组之间的神经活动模式。