Despite substantial efforts aimed at the detection and intervention for early symptoms of mental illness, there is relatively limited research on the clinical overlap between borderline personality disorder (BPD) and early psychosis, for example, clinical high risk (CHR) for psychosis, in young people. We present a narrative review of the clinical overlap between BPD and psychosis spectrum symptoms. Both conditions have unstable temporal course, and both are marked by functional impairment, increased suicide risk, and higher rates of psychiatric inpatient services. We then review evidence-based treatments for psychosis and BPD, emphasizing treatments for early presentations of these symptoms and initial research considering treatments for the overlap. Psychotherapies with the strongest empirical support include cognitive behavioral models, with BPD showing limited response to adjunctive pharmacotherapy. We end by discussing specific recommendations for future research, including longitudinal studies to determine the predictors of the course of illness and the development of treatments to target comorbid BPD and CHR symptoms.

中文翻译：

---

共病早期精神病和边缘型人格障碍：临床重叠、病因和治疗的概念化

尽管在精神疾病的早期症状的检测和干预方面做出了大量努力，但对边缘型人格障碍 (BPD) 和早期精神病之间的临床重叠的研究相对有限，例如，青少年精神病的临床高危 (CHR)人们。我们对 BPD 和精神病谱症状之间的临床重叠进行了叙述性回顾。这两种情况都有不稳定的时间过程，并且都以功能障碍、自杀风险增加和精神病住院服务率较高为特征。然后，我们回顾了精神病和 BPD 的循证治疗方法，强调对这些症状的早期表现进行治疗，并考虑对重叠进行治疗的初步研究。具有最强实证支持的心理疗法包括认知行为模型、BPD 对辅助药物治疗的反应有限。我们最后讨论了对未来研究的具体建议，包括纵向研究，以确定疾病进程的预测因素以及针对合并 BPD 和 CHR 症状的治疗的发展。