Abstract

Recently, researchers are exploring the potential of polymer chemistry a lot in therapeutics. In conventional non-targeted polymeric drug delivery, an array of unwanted side effects was identified due to the release and distribution of therapeutic molecules into healthy cells. Consistent efforts are made to diminish such effects by encapsulating drug molecules into a well-developed stimuli-responsive nanocarrier that directly affects cells. Herein, we have designed to synthesize a nanocarrier, which was developed to carry any hydrophobic drug moiety through the bloodstream and finally target the infected area. For the greater assembly of molecules in the aqueous medium, we have incorporated self-assembly criteria into our design in the simplest way. Caprolactone (hydrophobic) and polyethylene glycol derivative (hydrophilic) were carefully chosen as the components to integrate amphiphilicity to the system to guarantee well organized self-assembled structures. Click chemistry (being stereospecific, simple to perform, broad in scope and most importantly high yielding) is a very productive method that is used in the synthetic procedure of connecting the new initiator molecule with the hydrophilic and hydrophobic part of the system. It is done just after the successful process of ring-opening polymerization. The critical micelle concentration of the self-assembled nanocarrier was found to be 235 μg/mL and the hydrodynamic radius measured using dynamic light scattering was noted as 24 nm. The micelles formed in aqueous solution were observed as spherical in shape under scanning electron microscope as well as transmission electron microscope.

摘要

最近，研究人员正在大量探索高分子化学在治疗中的潜力。在传统的非靶向聚合物药物递送中，由于治疗分子释放和分布到健康细胞中，确定了一系列不需要的副作用。通过将药物分子封装到直接影响细胞的成熟的刺激响应纳米载体中，我们一直在努力减少这种影响。在此，我们设计合成了一种纳米载体，该载体被开发用于通过血流携带任何疏水性药物部分，并最终靶向感染区域。为了在水性介质中进行更大的分子组装，我们以最简单的方式将自组装标准纳入我们的设计中。己内酯（疏水性）和聚乙二醇衍生物（亲水性）被仔细选择作为将两亲性整合到系统中的组分，以保证组织良好的自组装结构。点击化学（立体定向、操作简单、范围广泛且最重要的是收率高）是一种非常有效的方法，用于将新引发剂分子与系统的亲水和疏水部分连接的合成过程。它是在成功的开环聚合过程之后完成的。发现自组装纳米载体的临界胶束浓度为 235 μg/mL，使用动态光散射测量的流体动力学半径为 24 nm。