Introduction: The regional cerebral blood flow (rCBF) distribution can affect brain functioning, leading to amnestic mild cognitive impairment (aMCI) and mild Alzheimer disease (AD). This study aimed to clarify the detailed characteristics of rCBF distribution in patients with mild AD and aMCI. Methods: This cross-sectional study from April 2015 to March 2018 included 103 older adults (mean age 78.9 years; 60% females), out of a total of 302 adults, and categorized them into 3 groups according to cognitive symptoms. The normal control (NC), aMCI, and mild AD groups included 20, 50, and 33 participants, respectively. The primary outcome was rCBF, which was compared among the 3 groups using a 2-sample t test without correction for multiple comparisons. Results: In the aMCI group, the rCBF decreased in the bilateral parietal and left frontal association cortex and the bilateral premotor cortex (p #x3c; 0.01) but increased in the bilateral cerebellum (p #x3c; 0.01). In the mild AD group, the rCBF decreased in the bilateral parietal and occipital association cortex, the bilateral premotor cortex, the left temporal and frontal association cortex, and the left limbic lobe (p #x3c; 0.01). Conversely, the rCBF increased in some parts of the cerebellum, the bilateral frontal and temporal association cortex, the left occipital association cortex, and the right premotor cortex (p #x3c; 0.01). Conclusion: Based on the analysis of the values obtained, it was inferred that the rCBF undergoes reduction and elevation in aMCI and AD patients.
Dement Geriatr Cogn Disord Extra 2021;11:91–98

中文翻译：

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单光子发射计算机断层扫描在阿尔茨海默病和轻度轻度认知障碍中局部脑血流的特征：跨领域研究

简介：区域性脑血流量（rCBF）分布会影响脑功能，导致轻度认知障碍（aMCI）和轻度阿尔茨海默病（AD）。这项研究旨在阐明轻度AD和aMCI患者的rCBF分布的详细特征。方法： 2015年4月至2018年3月的这项横断面研究纳入了302名成年人中的103名老年人（平均年龄78.9岁;女性占60％），并将其根据认知症状分为3组。正常对照组（NC），aMCI和轻度AD组分别包括20、50和33名参与者。主要结果是rCBF，使用2样本t检验比较了3组之间的rCBF，没有进行多次比较的校正。结果：在aMCI组中，rCBF在双侧顶叶和左额叶缔合皮层和双侧运动前皮层中降低（p＃x3c； 0.01），而在双侧小脑中升高（p＃x3c； 0.01）。在轻度AD组中，双侧顶叶和枕叶联合皮层，双侧前运动皮层，左颞叶和额叶联合皮层以及左缘叶的rCBF降低（p＃x3c; 0.01）。相反，rCBF在小脑，双侧额叶和颞叶相关皮层，左枕骨相关皮层和右前运动皮层的某些部位增加（p＃x3c； 0.01）。结论：根据获得的值的分析，可以推断出，aMCI和AD患者中rCBF会降低和升高。
Dement Geriatr Cogn Disord Extra 2021; 11：91–98